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When Amy and Michael take Katie on a road trip to her college orientation, they pass a familiar campsite and decide to stop and hike the trail. The journey quickly becomes harrowing when they discover an injured man whose life hangs in the balance. Stranded in the middle of nowhere, with no cell service, it's up to the three of them to somehow save him.

After a tragic accident, one of Joan's oldest friends is rushed to Minneapolis to be treated by her, forcing Amy to confront her about her illness. Richard and TJ find themselves at odds when they treat a tech bro who thrives on pushing boundaries. Michael tries to pick up the pieces in the wake of his fractured marriage.

Met with hostility upon his return, Richard looks to redeem himself while treating an overworked food delivery worker. Sonya and TJ enlist Jake's help with the delicate Joan situation. Amy and TJ take on the case of a well-known medical malpractice lawyer, leading to unexpected complications.

While navigating the fallout from Katie's secret, Amy treats a critically ill patient with a dark one of her own. Gina and Jake evaluate a world-class poker player. Sonya and TJ investigate their theory behind Joan's frequent absences and Richard returns with a trick up his sleeve.

Amy and Jake treat an expectant mother injured during a robbery. Michael is challenged to open up when Katie's therapist invites him and Amy to a session. TJ and Sonya help Julie navigate a mysterious illness and an unexpected romance.

The race for Chief resident intensifies as Joan tasks Amy and Sonya with evaluating each other's case work. Amy tends to a politician with a disability. Sonya struggles to find a solution to her combative patient's abdominal pain. Michael's parents come to town.

Charlie fights for his life at Westside with Hannah by his side. The Board launches an internal investigation into Brian Clark's resignation, putting everyone in the hot seat. A familiar face returns to Westside.

The search for Amy's hacker intensifies. Hannah, devastated by the death of her patient, works with Amy to treat a sick man whose daughter believes has been poisoned. Meanwhile, Sonya and TJ examine middle school kids for scoliosis.

With the search underway to find out the truth about Amy's hacked accounts, she and Sonya butt heads while treating a homeless patient. Jake and TJ help a distraught mother figure out why her daughter is in a coma. Hannah cares for a charming high school athlete.

Grief helps clarify Jake's feelings for Amy, and a flashback to the pandemic reveals the truth about why he stayed at Westside. To Hannah's surprise and dismay, Charlie goes too far with their plan to destroy Amy, causing explosive repercussions.

Jake refuses to give up on a beloved patient, landing himself in conflict with several Westside surgeons and when Amy's neuro tests elicit memories of Danny, she pushes herself too far.

Amy and Gina, with an assist from Jake, team up to help a victim of domestic abuse, while TJ finds himself in the spotlight when he, Sonya and Liz treat a social media influencer.

Amy treats a Chaplain who helps her reconcile with the past, while Michael is under investigation for his actions during the hostage crisis.

A popular weight loss medication reveals the cracks in a couple's relationship and two sisters face an unexpected diagnosis.

An outdated medical proxy form creates tension between a patient's ex-husband and current partner. Amy, Jake, and new intern Hannah investigate a college student's sudden blindness.

A patient forces Amy to confront the realities of medical tourism, TJ helps a veteran with his prosthetic and Joan drops a bombshell.

Amy struggles with memories during treatment of an expectant mother's puzzling illness. Her mentor Dr. Joan Ridley makes a visit to Westside.

Amy's past comes back to haunt her when a desperate father sacrifices everything to secure his daughter's heart transplant.