Three Rivers

When a woman's husband needs a new kidney, she contemplates beginning a "Daisy Chain"; which means she will donate a kidney to someone and they in turn will donate their kidney until the chain is completed with her husband getting his kidney. Andy is not sure he wants to support such an action and he is concerned that another patient is rejecting his recently transplanted heart.

The wife of a billionaire suffers the consequences after a setback leaves her without a new liver and her husband resorts to buying one on the black market. Meanwhile, a friend from Andy's past resurfaces.

Andy and Sophia treat a car crash victim named Victor dying from ALS who asks to be to taken off of life support so his organs can be used to save others. Meanwhile, David tends to a foster parent with pulmonary hypertension who refuses admission to the hospital.

Lisa becomes very attached to an 8-year-old boy who she witnesses being crushed by a ride at a fair. Meanwhile, Andy and David try to get a VAD (ventricular assist device) for one of their patients.

In order to save his life, Andy tries a risky new procedure on his wife's partner who suffers from an aortic aneurysm.

Following a bus crash, the parents of a football player must make a heartbreaking decision whether to donate his organs. Meanwhile, Andy and Ryan rush to find a procurement team to give a boy a heart transplant he desperately needs.

Claiming he has turned his life around, Andy (Alex O'Loughlin) convinces UNOS to give a former drug addict names Scott (Shiloh Fernandez) a new heart.

An 18-year old in need of a double-lung transplant, struggles to survive as the team runs into an obstacle that may prevent her from being eligible for the procedure.

After suffering a heart attack, Andy tells a young pregnant woman that in order to save her and her unborn child she must get a heart transplant. However, unexpected complications with the donor's family place the transplant in jeopardy.