Unusual Suspects

A 40-year-old mother disappears from her home in the middle of the night, and police chase multiple leads before coming up empty. Almost a year goes by until they investigate a very unlikely suspect - a high-school neighbor with an affinity for older women. Then, a teenage boy is murdered in his home and detectives believe his campaign against teen gang activity led to his death. But the community is horrified when police arrest one of their "model citizens" for ordering the hit.

A husband and wife are found shot to death on a deserted stretch of highway. Phone records help detectives uncover a murder-for-hire plot that went horribly wrong, and discover that one of their victims is also their prime suspect. Next, when a 20-year-old woman is found murdered near a freeway exit ramp, the residents of San Diego demand justice. But when a trusted police officer is identified for the crime, the community is shaken to its core.

A young boy is killed in the middle of the night, and his own mother is convicted of the crime. Years later, an author investigates a convicted murderer for her upcoming novel, and gets a confession that re-opens that case file and eventually, sets the mother free.

In 1996, teenaged Joey Martin sneaks out of his bedroom window to watch a comet from a cabin in the woods-and disappears. Despite multiple leads, there is no sign of Joey until 2008 when a young detective uncovers the shocking story of Joey's fate.

In 1985 when welder Danny Paquette is killed in his front yard by a long-distance rifle shot, there is no shortage of suspects. Many people had issues with Danny. But ultimately the solution falls much closer to home than anyone expected.

When 10-year-old Katie Collman is murdered in a small Indiana town, a shocking confession catapults this crime into national news. Was Katie murdered to keep her quiet about something she saw? An unusual clue leads investigators to the conclusion.

Season 3 premiere. An attack on a Pennsylvania family that left only one survivor is discussed.

The 1994 murder of Missy Grubaugh is discussed.

The murders of three Arlington, Texas, teenagers in 1985 and the subsequent homicide investigation are discussed.

The 1995 death of a Chicago woman whose body was found on a Wisconsin highway is detailed in the Season 4 premiere.

In Arkansas, three women are murdered over the course of three years.

The 1995 murder of an 8-year-old girl sparks a manhunt for her killer.

The fifth season opens with a case involving a high-school girl who was murdered in 1985.

A Georgia woman is murdered just before Christmas.

A cold case involving a 1988 murder in Sunset Beach, Cal., is investigated.

The Season 6 opener features a serial-rapist case in Reno.

Investigating the 1989 murder of a high-school student.

A Kentucky woman is found dead in the trunk of her car.

Shortly before Thanksgiving, a Philadelphia suburb is rocked by the murder of 67-year-old Alice Hufnagle.

In Portsmouth, Va., a 16-year-old ballet dancer is assaulted and murdered in her home, and detectives must investigate her family members as well as her circle of friends.

When a college student is found murdered in his Arlington, Texas, apartment, investigators suspect the kindhearted victim's generosity may have led a killer to his door.

The murder of a popular young woman in Lancaster County, Pa., is investigated.

The murder of a young woman in her Portland, Ore., apartment is investigated.

The strangulation death of an 8-year-old girl in Ocean Shores, Wash., is investigated.

On a summer day in Springfield, Illinois, an infant daughter left in a sweltering SUV is the only sign of a young mother that's gone missing. A frantic search leads to an eerie sight at the edge of town, and a killer who may have more secrets to expose.

In Southern California, police investigate the murders of married entrepreneurs who may have found out the hard way that no amount of money is worth losing one's life over.

A fun-loving New Jersey woman buys a home close to her family, then the wrong houseguest proves deadly, and police must dig through the victim's life to find an enemy who hides very close.